Nocturnal Home Hemodialysis and Short Daily Hemodialysis Compared With Kidney Transplantation: Emerging Data in a New Era - Robert P. Pauly
Link to abstract. Advances in Chronic Kidney Disease - 16:3:169-172 - May 2009
New evidence suggests that such intensive dialysis is associated with improved survival compared with traditional 3-times-a-week hemodialysis and may have a survival advantage comparable to that seen with deceased donor transplantation. If confirmed, these new findings have significant implications for the delivery of care to the ESRD population and warrant further study.
Case Mix, Quality and High-Cost Kidney Transplant Patients - M. J. Englesbe, J. B. Dimick, Z. Fan, O. Baser, J. D. Birkmeyer
Link to abstract. American Journal of Transplantation - 9:5:1108-1114 - May 2009
Payments for high-cost patients represent a significant proportion of the total costs of kidney transplant surgical care. Quality improvement may be an important strategy for reducing the costs of kidney transplantation.
Reducing De Novo Donor-Specific Antibody Levels during Acute Rejection Diminishes Renal Allograft Loss - M. J. Everly, J. J. Everly, L. J. Arend, P. Brailey, B. Susskind, A. Govil, A. Rike, P. Roy-Chaudhury, G. Mogilishetty, R. R. Alloway, A. Tevar, E. S. Woodle
Link to abstract. American Journal of Transplantation - 9:5:1063-1071 - May 2009
De novo DSAs detected at rejection are associated with reduced allograft survival, but prompt DSA reduction was associated with improved allograft survival. DSA should be considered a potential new end point for rejection therapy.
The Development of Kidney Transplant Nursing - Nancy Hoffart
Link to full text article. (pdf format requires Adobe Acrobat reader) Nephrology Nursing Journal - 36:2:127 - March/April 2009
An analysis of published literature, interviews with early transplant nurses, and other primary source materials shows how evolving medical treatments for rejection, nurses’ ability to learn on the job, and their commitment to patients influenced the development of kidney transplantation as a specialized area of practice. The work of these nurses work is discussed in the context of unfolding nursing specialization at the middle of the twentieth century.
Prediction of the severity and outcome of acute tubular necrosis based on continuity of Doppler spectrum in the early period after kidney transplantation - Aureliusz Kolonko, Jerzy Chudek, and Andrzej Wicek
Link to abstract. Nephrology Dialysis Transplantation - 24:5:1631-1635 - May 2009
The discontinuous spectrum of flow in the segmental arteries of the kidney graft in the early period after KTx is typical for ATN and predicts its duration.
Reappraisal of HLA Antibody Analysis and Crossmatching in Kidney Transplantation - P.-C. Lee, M. Ozawa, C.-J. Hung, Y.-J. Lin, S.-S. Chang, T.-C. Chou
Link to full text article. (pdf format requires Adobe Acrobat reader) Transplant Proceedings - 41:1:95-98 - January/February 2009
In conclusion, virtual XM concept relies on accurate HLA typing and thorough evaluation of HLA Abs using solid-phase assays. Although a negative virtual XM has proven to be reliable to exclude the presence of donor-pecific HLA Abs, it becomes a greater concern whether all HLA Abs detected by flow-beads are in fact clinically relevant. The virtual XM approach–in which Abs are characterized using solid-phase assays prior to crossmatching-has been reported to predict a negative flow XM in 90% of cases. The predictive value for a correct CDC XM, however, was only 75%. A potential disadvantage of the virtual XM approach is that transplants may be excluded based on Ab results with unknown clinical relevance. Based on our results, we believe HLA Ab identification using ELISA still has a role to predict long-term graft survival and a NPV for a CDC XM before transplantation. Further analysis of HLA Abs using the Luminex assay must be performed to compare with the present data.
